Abstract # 2877 Surviving Fraction (SF2) and Clonogen Cell Density (CCD) are the Dominant Predictors of Tumor Control Probability (TCP) in High Grade Glioma

Presenter: Ahmad, Salahuddin

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Results:
SF2 was the major determinant of TCP. Specifically, average TCP was above 99% for SF2 of 0.3 and below 1% for SF2 of 0.8 irrespective of CCD. Inverse relationship between CCD and TCP was observed for SF2 of 0.4 to 0.7. Specifically, progressively increasing CCD values from 100 to 2 X 108 cells/cc resulted in TCP reduction from 100% to 89.8% for SF2 of 0.4, 100% to less than 1% for SF2 of 0.5, 99.7% to 0% for SF2 of 0.6 and from 75% to 0% for SF2 of 0.7. Smaller TCP decreases were noted with decreasing α/β ratios.