Abstract # 2305 Extramural Validation of the Mayo Clinic Prognostic Scoring System for Postprostatectomy Biochemical Failure in Patients Salvaged with a Regimen Combining Radiotherapy and Hormones

Presenter: Eapen, Libni

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Results:
Between 1984 and 2005 141 pts met the criteria. They ranged in age from 47-75 yrs (median 62) with stage pT1/T2/T3/T4/Tx in 2.1/43.9/1.4/3.5%. Gleason scores were 7 in 47/35.1/17.9%. PreRT psa ranged from 0.1-15.0(mean/median=1.8/0.68) with psa <.5/.5-1/>1 in 37.6/20.6/41.8%. Mayo prognostic scores (Ottawa pts/Mayo pts) were 0-1 35.7/29.9%: 2= 29.5/25.8%: 3=20.9/17.1%: 4-5=14/11.7%. Radiotherapy consisted of 4 field box or conformal techniques treating the prostate bed alone or including an abbreviated pelvic nodal volume to a median dose of 66GY in 33 fractions. Hormone duration in months was 3/3-6/6-9/>9 in 25.5/26.9/17.7/29% and was given during RT in all pts, neoadjuvantly in 21.3% and adjuvantly in 46.9% Median follow up=46 months (range 1-177 mths). 8/141 (5.7% had pelvic recurrence. Biochemical recurrence free surviva l (brfs) at 5yrs/8yrs were Ottawa 80.3%/63% and Mayo 46%/35%. Overall 5 yr/8yr survivals were Ottawa 84%/67.4% and Mayo 92%/80%. Brfs at 5 yrs according to prognostic scores were Ottawa/Mayo: 1=90/78%, 2=85/60%, 3=80/30%, 4-5=42/10%. Chronic GU/GI toxicity scores were: grad 3 7pts/4pts and grade 4 1pt/0.