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Results:
A total of 187 of 1738 men (11%) had a family history of prostate cancer in a first degree relative. Men with a family history were significantly younger (median age 65 vs 67, p = <0.001), and had fewer low-dose implants measured by the BED<150 Gy 2 (2.7% vs 10.8%, p<0.001) than those without a family history but other baseline and treatment characteristics were similar between the two groups. For the low risk patients, both groups had similar actuarial 5-year freedom from biochemical failure (FFBF) (95%). For intermediate risk patients there was a trend towards improved biochemical control in men positive for family history, 5-yr FFBF 100% vs. 93%, p=0.069. For the high risk patients, men with a positive family history had improved 5-year FFBF 94% vs 80%, p=0.049. On multivariate analysis, family history did not remain significant; use of hormones, high BED, initial PSA, and Gleason score were the significant variables predicting biochemical control.
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