Abstract # 2254 Comparisons of PSA Failure Definitions Following Trimodality Therapy for Intermediate to High-Risk Prostate Cancer

Presenter: Stock, Richard

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Results:
The actuarial freedom from PSA failure rates for the three definitions were similar. At 3 years the rates were: 92%(ASTRO), 94%(PHNX) and 88%(AUA). At 5 years the rates were: 89%(ASTRO), 88%(PHNX), 84%(AUA). At 8 years the rates were: 87%(ASTRO), 83%(PHNX), 83%(AUA). There were no differences between the ASTRO and PHNX actuarial curves (p=0.9) and ASTRO and AUA curves (p=0.058). There was a significant difference between the curves for the AUA and PHNX definitions (P=0.04). There were more failures using the AUA (75) compared to the ASTO (55) and the PHNX (55) definitions but this was not significantly different (p=0.09). The last PSA levels for the 17 patients defined as an AUA failure but not an ASTRO or PHNX ranged from 0.23 to 1.79 ng/ml (median - 0.34 ng/ml). Of these patients, none have developed a clinical (local or distant) recurrence nor have any been started on hormonal therapy.