Abstract # 1030 Improved Local Control Associated with Dose-escalated Stereotactic Body Radiation Therapy (SBRT) Indicates Dose-response Relationship

Presenter: McCammon, Robert

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The local control rate of treated tumors improved with increased dose, expressed as either nominal dose or EUD. At a median follow-up of 8.4 months (18.3 months for living patients, 5.9 months deceased), lesions treated to a nominal dose of 54 Gy had a 3-year actuarial local control rate of 89.3%, whereas the values for those treated to 36.1-53.9 Gy and <36 Gy were 59.7% and 8.7%. Likewise, lesions treated with the highest third of EUD (>64.3 Gy) had a 3-year local control rate of 90.6%, compared to 56.0% in the middle third (43.5-64.3 Gy, p=0.0047) and 9.9% in the lowest third (<43.5 Gy, p<0.0001). On univariate and multivariate analysis, increased dose (nominal or EUD) was a statistically significant predictor of improved local control. Patient age, gender, tumor histology, primary site, duration of treatment, and clinical context (primary v metastasis) did not predict for local control on either univariate or multivariate analysis. Treatment was well tolerated; 3.4% of patients experienced a grade 3 toxicity.