Abstract # 1012 Match Pair Analysis of Early Stage Breast Cancer Treated with Accelerated Partial Breast Irradiation or Whole Breast Radiation Therapy with 12 Year Follow-Up

Presenter: Antonucci, John

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Mean follow-up for surviving patients was 11.4 years (13.7 yrs WBRT vs. 9.4 yrs APBI, p<0.001). Differences in characteristics were non-significant except for higher re-excision in the WBRT group (p<0.001) and more adjuvant chemotherapy in the APBI group (p=0.01). Overall, 16 local failures occurred during the follow-up period, 8 per group. Twelve-year IBTR rates were 4% for WBRT compared to 5% for APBI (p=0.5). No differences were seen in the time to failure or the distribution of CR vs CD IBTRs by treatment type (Table). CD failures had a longer time to failure compared to CR (8.3 yrs vs 4.6 yrs, p=0.05). No differences were seen in the 12-yr rates of FFF, RNF, DMFS, CSS, or 5-yr DFS after IBTR (Table). On multivariate analysis (MVA) for all patients, lack of adjuvant Tamoxifen (p=0.04) and age (p=0.03) were significantly associated with IBTR. Analysis by treatment group identified no factors associated with IBTR for APBI and age associated with IBTR for WBRT (p=0.001). For the entire cohort, MVA showed significance for age on CD failure (p=0.04) and adjuvant Tamoxifen for CF (p=0.03). For APBI, use of chemotherapy resulted in a lower risk of CF (p=0.006). No differences were seen in long-term cosmetic outcomes (Excellent/Good: 96% WBRT vs. 99% APBI, p=0.1).