Abstract # 2877 Surviving Fraction (SF2) and Clonogen Cell Density (CCD) are the Dominant Predictors of Tumor Control Probability (TCP) in High Grade Glioma

Presenter: Ahmad, Salahuddin

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Purpose/Objective:
High grade glioma has a poor prognosis despite treatment with surgery followed by adjuvant chemotherapy and radiation. TCP modeling to predict tumor responses uses variables such as the α/β ratio, CCD and SF2 but their exact value is not known and may vary amongst patients or even amongst different clonogens or regions within the same tumor. In this study, we used various combinations of α/β, SF2 and CCD to determine TCP and identify their relative contributions in radio resistance for high grade glioma patients treated with IMRT.