Abstract # 1030 Improved Local Control Associated with Dose-escalated Stereotactic Body Radiation Therapy (SBRT) Indicates Dose-response Relationship

Presenter: McCammon, Robert

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The records of 152 consecutive patients treated with SBRT from October 1999 through August 2005 were retrospectively reviewed on an IRB-approved protocol. A total of 261 lesions in the lungs, liver, or other extracranial sites were treated; 18% (27/152) of patients were treated on formal prospective Phase I/II studies. Patients ineligible or those who declined to participate in the dose-escalation studies were treated with the highest safe dose established at the time of treatment. A nominal dose of 30 Gy was prescribed to 84% of the lesions, and 97% were treated in a 3 fraction course. Local control was assessed via serial imaging with CT, MRI, and/or PET/CT. The equivalent uniform dose (EUD) was tabulated for each lesion from dose-volume histogram (DVH) data, and local control was evaluated according to both nominal dose and EUD. A multivariate analysis was performed to identify patient or treatment factors associated with increased local control.