Abstract # 2877 Surviving Fraction (SF2) and Clonogen Cell Density (CCD) are the Dominant Predictors of Tumor Control Probability (TCP) in High Grade Glioma

Presenter: Ahmad, Salahuddin

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TCP modeling predicts that SF2 is the dominant predictor of radioresistance followed by CCD. Relating clinical and molecular prognostic indicators to SF2, α/β and CCD will improve our ability to more precisely model response to therapy in high grade glioma. Combining TCP modeling with functional imaging will allow us to map tumor regions of higher grade and/or density and selectively intensify therapy using higher radiation doses with or without targeted agents. This will optimize target coverage while minimizing normal tissue damage and may improve the outcome of patients with high grade glioma.