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Conclusions:
When applying PSA failure definitions to a high BED treatment such as trimodality therapy, the original ASTRO definition remains viable and yields similar results as the PHNX and AUA definition. Although the AUA calls more failures, these appear to be overestimates based on clinical correlations. This increase in failures is not statistically significant and does not result in a difference between the actuarial curves of the AUA and ASTRO definitions. This suggests that the AUA definition could be used in trials comparing prostatectomy to trimodality therapy.
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