Abstract # 2009 Contralateral Breast Cancers Within 5 Years of Conservative Surgery and Radiation: Implications for Breast MRI

Presenter: Silverman, Joshua

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Conclusions:
The incidence of CBC within 5 years after in-situ or early stage invasive breast cancer is similar between this population and the rate of MRI-detected, biopsy proven CBCs at the time of diagnosis in the N Engl J Med study (2.8% v. 3.1%). CBCs in this study were slightly larger (median 1.5 cm vs. 1.09 cm) and less often DCIS (18% vs. 40%) than in the MRI-detection study. This may be consistent with a model that MRI is detecting initially occult CBC that would have become evident within 5 years. An alternative model that can explain the similar rates between studies is that MRI detects many CBCs that would not otherwise have become clinically apparent and there will continue to be an incidence of de novo CBCs by 5 years. Whether MRI translates into improved outcome benefit that justifies additional costs, morbidity and biopsies remains an open question.